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راه اندازي تشخيص همزمان وارونگي هاي اينترون هاي 22 و 1 ژن فاكتور هشت انعقادي

راه اندازي تشخيص همزمان وارونگي هاي اينترون هاي 22 و 1 ژن فاكتور هشت انعقادي

    
آرشيو اخبار
 

Characterization of SARS-CoV-2 isolated from a patient in Iran compared to SARS-CoV-2 different variants

Interactions of heparin derivatives with recombinant human keratinocyte growth factor: Structural stability and bioactivity effect study

Characterization of a novel mCH3 conjugated anti-PcrV scFv molecule

Serum Calprotectin as a Blood-Based Biomarker for Monitoring Knee Osteoarthritis at Early but Not Late Stages

Effect of bisphenol A on alterations of ICAM-1 and HLA-G genes expression and DNA methylation profiles in cumulus cells of infertile women with poor response to ovarian stimulation

T lymphocytes and preeclampsia: The potential role of T-cell subsets and related MicroRNAs in the pathogenesis of preeclampsia

Development and Characterization of a Novel Single-Chain Antibody Against B-Cell Activating Factor

Design peptide and multi-epitope protein vaccine candidates against monkeypox virus using reverse vaccinology approach: an in-silico study

TERT Promoter Mutation in Benign and Malignant Salivary Gland Tumors; A Cross-Sectional Study

In silico Analysis of Two Novel Variants in the Pyruvate Carboxylase (PC) Gene Associated with the Severe Form of PC Deficiency

Design of ion channel blocking, toxin-like Kunitz inhibitor peptides from the tapeworm, Echinococcus granulosus, with potential anti-cancer activity

The chicken chorioallantoic membrane model for isolation of CRISPR/cas9-based HSV-1 mutant expressing tumor suppressor p53

Frequency and prognostic influence of ASXL1 mutations and its potential association with BCR-ABL1 transcript type and smoke in chronic myeloid leukemia patients

A Novel Fc-Engineered Anti-HER2 Bispecific Antibody With Enhanced Antitumor Activity

Targeting long non-coding RNA MALAT1 reverses cancerous phenotypes of breast cancer cells through microRNA-561-3p/TOP2A axis

MiR-548c-3p through suppressing Tyms and Abcg2 increases the sensitivity of colorectal cancer cells to 5-fluorouracil

CRISPR-Cas Technology as a Revolutionary Genome Editing tool: Mechanisms and Biomedical Applications

In silico Analysis of Two Novel Variants in the Pyruvate Carboxylase (PC) Gene Associated with the Severe Form of PC Deficiency

Delivery of dCas9 Activator System Using Magnetic NanoparticlesTechnology as a Vector Delivery Method for Human Skin Fibroblast

Targeted anti-tumor synergistic effects of Myc decoy oligodeoxynucleotides-loaded selenium nanostructure combined with chemoradiotherapy on LNCaP prostate cancer cells

MiR-548c-3p through suppressing Tyms and Abcg2 increases the sensitivity of colorectal cancer cells to 5-fluorouracil

Association of ABCB1, ABCG2 drug transporter polymorphisms and smoking with disease risk and cytogenetic response to imatinib in chronic myeloid leukemia patients

Discovery of potential FGFR3 inhibitors via QSAR, pharmacophore modeling, virtual screening and molecular docking studies against bladder cancer

Investigation the Role of Autophagy in Non-Small Cell Lung Cancer

Promoter Methylation of Tumor Suppressors in Thyroid Carcinoma: A Systematic Review

Impact of ABCB1 Gene Polymorphisms and Smoking on the Susceptibility Risk of Chronic Myeloid Leukemia and Cytogenetic Response

Genotypic variants of the tetrahydrobiopterin (BH4) biosynthesis genes in patients with hyperphenylalaninemia from different regions of Iran

Application of decoy oligodeoxynucleotides strategy for inhibition of cell growth and reduction of metastatic properties in nonresistant and erlotinib-resistant SW480 cell line

Immunoinformatics Approach to Design a Chimeric CD70-Peptide Vaccine against Renal Cell Carcinoma

Design of ion channel blocking, toxin-like Kunitz inhibitor peptides from the tapeworm, Echinococcus granulosus, with potential anti-cancer activity

Overexpression of Transmembrane Phosphatase with Tensin homology (TPTE) in prostate cancer is clinically significant, suggesting its potential as a valuable biomarker

Methylation Status of miR-34a and miR-126 in Non-Small Cell Lung Cancer (NSCLC) Tumor Tissues
آرشيو مقالات
 
15/04/1389
راه اندازي تشخيص همزمان وارونگي هاي اينترون هاي 22 و 1 ژن فاكتور هشت انعقادي

براي اولين بار در كشور تشخيص قبل از تولد وارونگي (inversion) اينترونهاي 22 و 1 ژن فاكتور هشت انعقادي با استفاده از روش Inverse-shifting PCR ( IS-PCR)  در گروه پزشكي مولكولي مركز تحقيقات بيوتكنولوژي انستيتو پاستور ايران  راه اندازي شد.

هموفيلي A يك بيماري خونريزي دهنده وابسته به جنس مغلوب است كه به علت نقص در ژن F8 رخ ميدهد. حدود 5000 بيمار هموفيلي A در كشور وجود دارند و در حدود 50-45 درصد موارد شديد اين بيماري به علت وارونگي در اينترونهاي 1 و 22 ژن  F8 رخ مي دهد. روشهاي قبلي براي تشخيص وارونگي اينترون 22 بر اساس southern blot و long-distant PCR بوده اند كه هر كدام داراي محدوديتهايي هستند. روش جديد( IS-PCR)  روشي نسبتا سريع بوده و همزمان مي تواند وارونگي اينترونهاي 1 و 22 را تشخيص دهد. همچنين از اين روش مي توان براي تعيين ناقلين وارونگي و تشخيص قبل از تولد نيز  استفاده كرد. اين روش در گروه پزشكي مولكولي راه اندازي شده و امكان ارائه خدمات تشخيصي براي مبتلايان به هموفيلي A و خانواده هاي آنان وجود دارد. همچنين امكان انتقال تكنولوژي تشخيصي  به دانشگاهها و  مراكز تشخيصي ژنتيك وجود دارد.
 
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