استراتژيها، توانمنديها و فعاليتها
هیچ اخباری در دسترس نیست
آرشيو اخبار
 

Bi-allelic variants in OGDHL cause a neurodevelopmental spectrum disease featuring epilepsy, hearing loss, visual impairment, and ataxia

Homozygous MEFV Gene Variant and Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis: A Family with a Novel Autosomal Recessive Mode of Inheritance

The Spectrum of Pathogenic Variants in Iranian Families with Hemophilia A

Quantitative evaluation of PpSP15-LmSTI1 fusion gene expression following transfection with an alphavirus-derived self-amplifying mRNA and conventional DNA vaccine platforms

A de novo TINF2, R282C Mutation in a Case of Dyskeratosis Congenital Founded by Next-Generation Sequencing

Delivery of dCas9 Activator System Using Magnetic Nanoparticles Technology as a Vector Delivery Method for Human Skin Fibroblast

Positive effect of acellular amniotic membrane dressing with immobilized growth factors in skin wound healing

A novel de novo canonical splice site mutation in the PTCH1 gene in a male patient with mild psychomotor retardation and autistic traits: a case report

Harnessing polyphenol power by targeting eNOS for vascular diseases

Multiplex Snapshot Minisequencing for the Detection of Common PAH Gene Mutations in Iranian Patients with Phenylketonuria

Overexpression of miR-32 in Chinese hamster ovary cells increases production of Fc-fusion protein

Frequency and prognostic influence of ASXL1 mutations and its potential association with BCR-ABL1 transcript type and smoke in chronic myeloid leukemia patients

Computational screening of FDA-approved drugs to identify potential TgDHFR, TgPRS, and TgCDPK1 proteins inhibitors against Toxoplasma gondii

Low incidence of microsatellite instability in gastric cancers and its association with the clinicopathological characteristics: a comparative study

Mitochondrial DNA Copy Number Variations in Gastrointestinal Tract Cancers: Potential Players

Regulatory Mutation Study in Cases with Unsolved Hypochromic Microcytic Anemia and α-Major Regulatory Element Haplotype Analysis in Iran

Multiplex Snapshot minisequencing for the detection of common PAH gene mutations in Iranian patients with Phenylketonuria

Aberrant promoter hypermethylation of miR-335 and miR-145 is involved in breast cancer PD-L1 overexpression

Chronic Obstructive Pulmonary Disease: Novel Genes Detection with Penalized Logistic Regression

Bi/tri-specific antibodies (HN-Fc-CD16 and HN-Fc-IL-15-CD16) cross-linking natural killer (NK)-CD16 and Newcastle Disease Virus (NDV)-HN, enhanced NK activation for cancer immunotherapy

The Common miRNAs between Tuberculosis and Non-Small Cell Lung Cancer: A Critical Review

Kindler epidermolysis bullosa-like skin phenotype and downregulated basement membrane zone gene expression in poikiloderma with neutropenia and a homozygous USB1 mutation

Comparing mRNA expression and protein abundance in MDR Mycobacterium tuberculosis: Novel protein candidates, Rv0443, Rv0379 and Rv0147 as TB potential diagnostic or therapeutic targets

reliminary study of Toxocara canis Recombinant Ctype Lectin as a suitable antigen for serodiagnosis of human toxocariasis

Identification of four novel mutations in VSP13A in Iranian patients with Chorea-acanthocytosis (ChAc)

Discovery of small molecules from natural compound databases as potent retinoid X alpha receptor agonists to treat Alzheimers disease
آرشيو مقالات
 
10/08/1402
Positive effect of acellular amniotic membrane dressing with immobilized growth factors in skin wound healing

The human amniotic membrane dressing has been shown to accelerate the wound healing process in the clinic. In this study, heparin was conjugated to a human Acellular Amniotic Membrane (hAAM) to provide affinity binding sites for immobilizing growth factors. To study the acceleration of the wound healing process, we bound epidermal growth factor and fibroblast growth factor 1 to heparinized hAAMs (GF-Hep-hAAMs). The heparinized hAAMs (Hep-hAAMs) were characterized by toluidine blue staining and infrared spectroscopy. The quality control of hAAM was performed by hematoxylin staining, swelling capacity test and biomechanical evaluation. The cytotoxicity, adhesion, and migration in vitro assays of GF-Hep-hAAMs on L-929 fibroblast cells were also studied by MTT assay, scanning electron microscopy, and scratch assay, respectively. Finally, in vivo skin wound healing study was performed to investigate the wound closure rate, re-epithelization, collagen deposition, and formation of new blood vessels. The results showed that GF-Hep-hAAMs enhance the rate of wound closure and epidermal regeneration in BALB/c mice. In conclusion, GF-Hep-hAAMs could accelerate the wound healing process, significantly in the first week.

 
صفحه اصلي | درباره ما | تاريخچه | گروه ها | ارتباط با صنعت | تماس با ما
Copyright © 2009   BRC All right Reserved Design By Ecomiran