19/07/1402
The role of miR-128 in cancer development, prevention, drug resistance, and immunotherapy
A growing body of evidence has revealed that microRNA (miRNA) expression
is dysregulated in cancer, and they can act as either oncogenes or
suppressors under certain conditions. Furthermore, some studies have
discovered that miRNAs play a role in cancer cell drug resistance by
targeting drug-resistance-related genes or influencing genes involved in
cell proliferation, cell cycle, and apoptosis. In this regard, the
abnormal expression of miRNA-128 (miR-128) has been found in various
human malignancies, and its verified target genes are essential in
cancer-related processes, including apoptosis, cell propagation, and
differentiation. This review will discuss the functions and processes of
miR-128 in multiple cancer types. Furthermore, the possible involvement
of miR-128 in
cancer drug resistance and tumor immunotherapeutic will be addressed.